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Which phrase accurately describes the mechanism of action and roles of conjugated equine estrogens (CEEs) in hormone replacement therapy? A. Binds to nuclear receptors in estrogen-sensitive tissues to replenish low hormone levels in menopause B. Protects against estrogen-stimulated endometrial proliferation


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Four conditions were used: systemic estrogen (50 µg/kg × 3 d, then every other day), placebo vaginal cream, preoperative low dose conjugated equine estrogen cream (CEE, 0.625 µg/d), and continuous CEE cream pre- and postoperatively (Supplemental Fig. 1). In each group, uninjured controls were compared with vaginal injury as a function of time.


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CEEs cream at 2 g (equivalent to 1.25 mg of CEE) were evaluated in a 24-week study in which women (n = 79) applied the vaginal cream daily for 21 days, and withheld treatment for 7 days. 4 Of the 28 women with biopsies of sufficient tissue at 24 weeks, there were two cases (2/28; 7.1%) of endometrial hyperplasia: one (3.6%) woman had simple.


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They received a topical vaginal application daily of 0.1 or 1% (w/w) PM cream or a conjugated equine estrogen (CEE) cream (a mixture of estrone, equilin, 17β-dihydroequilin, 17α-estradiol and 17α-dihydroequilin at 0.625 mg total estrogen/g cream) for 28 days. Estrogenic efficacy was assessed weekly by vaginal cytology assay and vaginal pH.


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Ovariectomized nulliparous rats were treated with estradiol or conjugated equine estrogens (CEEs) either systemically, vaginal CEE, or vaginal placebo cream for 4 wk. Low-dose local CEE treatment resulted in increased vaginal epithelial thickness and significant vaginal growth without uterine hyperplasia.


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CEEs cream at 2 g (equivalent to 1.25 mg of CEE) were evaluated in a 24-week study in which women (n = 79) applied the vaginal cream daily for 21 days, and withheld treatment for 7 days. 4 Of the 28 women with biopsies of sufficient tissue at 24 weeks, there were two cases (2/28; 7.1%) of endometrial hyperplasia: one (3.6%) woman had simple.


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Which phrase accurately describes the mechanism of action and roles of conjugated equine estrogens (CEEs) in hormone replacement therapy? Click the card to flip 👆 Binds to nuclear receptors in estrogen-sensitive tissues to replenish low hormone levels in menopause Click the card to flip 👆 1 / 47 Flashcards Learn Test Match Q-Chat morninggirl033